Assassin's Creed Brotherhood (ACB) es un videojuego de acción y aventura publicado y desarrollado por Ubisoft, lanzado en noviembre de 2010.
Este juego, que tiene lugar principalmente durante la época del Renacimiento italiano, pertenece a la serie Assassin's Creed. Su escenario encaja cronológicamente en la continuidad de Assassin's Creed II.
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